Weight Loss With Exenatide Treatment

Primary Outcomes

The primary objectives of this study is:

To investigate possible mechanisms and patterns of weight loss with exenatide treatment, especially among individuals who have robust early weight loss (greater than 5% weight loss in 12 weeks) with exenatide.

Secondary Outcomes

Our secondary objective is to identify metabolic characteristics that predict robust response to exenatide treatment.

Outcome measurements:

Weight

Body composition

Resting energy expenditure (REE)

Mixed meal test

Thermic effect of food

Serum metabolic parameters

Hunger/Nausea/Satiety visual analog scales (VAS)

Physical activity monitoring

Study Population

The study population will be generally healthy, non-diabetic women age 18-70 years with BMI 28-48 kg/m^2.