Boron Neutron Capture Therapy in Treating Patients With Melanoma

OBJECTIVES:

Determine the clinical response, by serial objective measurements, in patients with melanoma treated with boron neutron capture therapy.

Determine the time course, uniformity, and severity of acute dermal reactions in patients treated with this regimen.

Determine the late dermal reactions in patients who are followed for at least 6 months after treatment with this regimen.

Determine the pharmacokinetics of this regimen in these patients.

OUTLINE: Patients are stratified according to tumor size (no greater than 15 cc vs greater than 15 cc).

Patients undergo boron neutron capture therapy.

Patients are followed for 3 years.

PROJECTED ACCRUAL: A total of 36 patients will be accrued for this study within 3 years.